Quantitative magnetization transfer imaging of human brain at 7 T

Quantitative magnetization transfer imaging of human brain at 7 T

Quantitative magnetization transfer (qMT) imaging yields indices describing the interactions between free water protons and immobile macromolecular protons. These indices include the macromolecular to free pool size ratio (PSR), which has been shown to be correlated with myelin content in white matter. Because of the long scan times required for whole-brain imaging (≈20-30 min), qMT studies of ...

Pathological Assessment of Brain White Matter in Relapsing-Remitting MS Patients using Quantitative Magnetization Transfer Imaging

Introduction: Multiple sclerosis (MS) is characterized by lesions in the white matter (WM) of the central nervous system. Magnetic resonance imaging is the most specific and sensitive method for diagnosis of multiple sclerosis. However, the ability of conventional MRI to show histopathologic heterogeneity of MS lesions is insufficient. Quantitative magnetization transfer imaging (qMTI) is a rel...

Quantitative Magnetization Transfer Imaging of Human Brain at 3T using Selective Inversion Recovery

R. D. Dortch, K. Li, A. A. Tamhane, E. B. Welch, D. F. Gochberg, J. C. Gore, and S. A. Smith Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United Sta...

Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers

Quantitative magnetization transfer magnetic resonance imaging provides a means for indirectly detecting changes in the macromolecular content of tissue noninvasively. A potential application is the diagnosis and assessment of treatment response in breast cancer; however, before quantitative magnetization transfer imaging can be reliably used in such settings, the technique's reproducibility in...

Quantitative Magnetization Transfer Imaging Techniques and Applications